Captain Richard Evan Isaac was the son of a doctor. He was educated at Llandovery College and at the Welsh National School of Medicine Cardiff, qualifying in 1927. Before the war he held hospital appointments at Finchley Memorial Hospital, at Cardiff, and at Tunbridge Wells.
He worked for many years as a general practitioner in the Finchley and Barnet areas. During the war he served as a lieutenant colonel in the RAMC and served in Europe, the Middle East, India, and Malta.
From 1957 to 1958, he served as high sheriff of Cardiganshire. He was a founder member of the Aberystwyth Rotary Club and a past president of the Aberystwyth Rugby, Soccer and Athletic Clubs, and of the University of Wales Athletic Union. He was also a past Master of the Lyonsdown (Hertfordshire) Masonic Lodge and a past Provincial Grand Warden of both the Hertfordshire and South Wales Western Divisions.